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compounds of the invention wherein R 1 and R 2 are linked to form a ring can also be synthesized via Diels-Alder reactions (COT 537), as well as other cyclization, reactions with ketenes (COT, 1340-1345), annulations (COT, 1345-1362) and related reactions (COT, 537-560). The substituted tetracycline compounds of the invention have been found to be particularly effective for modulation of transcription and may be used in applications for regulation of transcription of genes or gene products known in the art.
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